Lactobacillus acidophilus Fermented Dandelion Improves Hyperuricemia and Regulates Gut Microbiota

نویسندگان

چکیده

Foodborne prevention and treatment of hyperuricemia (HUA) has received widespread attention. Lactic acid bacteria (LAB) can improve intestinal function, while traditional medicine dandelion the functions detoxification detumescence. Whether LAB fermented any effects on HUA underlying mechanism is not clear. To address these questions, Lactobacillus acidophilus was selected or maximal xanthine oxidase activity. The effect (LAFD) uric metabolism evaluated by mouse model. Expression levels UA, BUN, CRE, XOD, inflammatory factors in serum were detected. Paraffin sections staining used to observe kidney small intestine, mRNA expression GLUT9, URAT1, OAT1, ABCG2 related investigated. Furthermore, flora studied contents cecum high throughput 16S rRNA sequencing. results showed that LAFD had a significant inhibitory XOD vitro (p < 0.01). could reduce IL-1 β, IL-6, TNF- α 0.05), thus inhibiting reaction, reducing UA decreasing URAT1 increasing OAT1 intestine 0.05). In addition, gene sequencing analysis demonstrated help restore imbalance microbial ecosystem reverse changes Bacterodietes/Firmicutes, Muribaculaceae, Lachnospiraceae mice with HUA. It suggested treating may be regulation expressions as well flora, which provides experimental basis for development new plant products.

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ژورنال

عنوان ژورنال: Fermentation

سال: 2023

ISSN: ['2311-5637']

DOI: https://doi.org/10.3390/fermentation9040352